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Membrane Transporter/Ion Channel-
BMS-191095????????????ATP????????????mitoKATP?????????????????????????????????
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生物活性
Description
BMS-191095 is an activators of mitochondrial ATP-sensitive potassium (mitoKATP) channels.Target: potassium channelin vitro: BMS-191095 induces mitochondrial-depolarization and vasodilation. BMS-191095 elicites a dose-dependent vasodilation in endothelium denuded cerebral arteries with 8.1 ?? 2.3%, 31.6 ?? 2.1%, and 39.5 ?? 3.2% relaxation in response to 10, 50, and 100 ??M, respectively. in vivo: In normal rats, BMS-191095-induced vasodilation was mediated by mitochondrial depolarization and calcium sparks generation in VSM and was reduced by inhibition of BKCa channels.
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