"目录号: HY-14645A ee.: 99.69%
(+)-DHMEQ，低活性的DHMEQ对映体，是NF-κB的抑制剂。
相关产品
BAY 11-7082-JSH-23-Pyrrolidinedithiocarbamate ammonium-Parthenolide-(-)-DHMEQ-Ginsenoside C-K-QNZ-Dihydroartemisinin-Sulfasalazine-Andrographolide-RTA-408-Tomatidine-BAY 11-7085-Baicalin-Ginsenoside Rb1-
生物活性
Description
The (+)-DHMEQ, the distomer of DHMEQ, is a inhibitor of NF-κB. In vitro: (+)-DHMEQ down-regulat the NF-κB target genes IRF4 and CD40, the secretion of IL-6, CCL5, CCL17 and generated ROS. Cytotoxicity, CD30 down-modulation and CD30 shedding by (+)-DHMEQ are prevented by ROS scavenger NAC. [1] (+)-DHMEQ is a novel NF-κB inhibitor that induces apoptosis and cell-cycle arrest in several cancer cell types and promotes ROS generation, which causes genotoxic DNA damage in human liver cells. [2]
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