IntAct
https://www.ebi.ac.uk/intact/
Orchard S, et al. (2013) The MIntAct project - IntAct as a common curation platform for 11 molecular interaction databases. Nucleic Acids Research, 42(Database issue):D358-63, 13 Nov 2013, PMID: 24234451: Abstract, Article
IntAct provides a free, open source database system and analysis tools for molecular interaction data. All interactions are derived from literature curation or direct user submissions.
Contains molecular reactions between gene, protein and chemical entities.
License
IntAct is an open source, open data resource, available to anyone. Usage of IntAct material is covered by two licenses:
The terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, meaning you are free to use, reproduce and adapt our data providing you give appropriate credit, apply to all IntAct data, e.g. PSI-MI XML, MI-JSON and MITAB files, as well as data directly accessed via web pages/services.
The terms of the Apache License, Version 2.0 apply to all software relating to the functionality of IntAct, derived websites and webservices, the Curator Tool, SQL and Graph Database data dumps, and Art and Branding Materials.
下载数据：
FTP： ftp://ftp.ebi.ac.uk/pub/databases/intact/current
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intact.txt.gz：一行为一条互作关系记录，A-B interaction
具体说明见：intact文件列的说明.xls
| 标题 | 解释 | 例子 |
|---|---|---|
| #ID(s) interactor A | A的id | uniprotkb:P49418 |
| ID(s) interactor B | B的id | uniprotkb:O43426 |
| Alt. ID(s) interactor A | 其他数据库来源的id | intact:EBI-7121510\ |
| Alt. ID(s) interactor B | 其他数据库来源的id | intact:EBI-2821539\ |
| Alias(es) interactor A | 其他名字 | psi-mi:amph_human(display_long)\ |
| Alias(es) interactor B | 其他名字 | psi-mi:synj1_human(display_long)\ |
| Interaction detection method(s) | 互作检测方法 | psi-mi:"MI:0084"(phage display) |
| Publication 1st author(s) | 发表的第一作者 | Cestra et al. (1999) |
| Publication Identifier(s) | pubmed medline | pubmed:10542231\ |
| Taxid interactor A | 10 A所属物种 | taxid:9606(human)\ |
| Taxid interactor B | 11 B所属物种 | taxid:9606(human)\ |
| Interaction type(s) | 12 互作的类型 | psi-mi:"MI:0407"(direct interaction) |
| Source database(s) | 来源的数据库 | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) | 互作识别id | intact:EBI-7121552\ |
| Confidence value(s) | 置信值 | intact-miscore:0.56 |
| Expansion method(s) | 展开方式 | - |
| Biological role(s) interactor A | 生物学作用 | psi-mi:"MI:0499"(unspecified role) |
| Biological role(s) interactor B | 生物学作用 | psi-mi:"MI:0499"(unspecified role) |
| Experimental role(s) interactor A | 实验的作用 | psi-mi:"MI:0498"(prey) |
| Experimental role(s) interactor B | 实验的作用 | psi-mi:"MI:0496"(bait) |
| Type(s) interactor A | 所属类型 | psi-mi:"MI:0326"(protein) |
| Type(s) interactor B | 所属类型 | psi-mi:"MI:0326"(protein) |
| Xref(s) interactor A | 链接其他数据库 | ensembl:ENST00000325590\ |
| Xref(s) interactor B | 链接其他数据库 | reactome:R-HSA-1660499\ |
| Interaction Xref(s) | - | |
| Annotation(s) interactor A | 注释 | function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton\ |
| Annotation(s) interactor B | 注释 | comment:"Stoichiometry: 1.0" |
| Interaction annotation(s) | 互作的注释 | comment:homomint\ |
| Host organism(s) | 宿主的物种 | taxid:-1(in vitro)\ |
| Interaction parameter(s) | - | |
| Creation date | 创建记录日期 | 2001/1/10 |
| Update date | 更新记录日期 | 2014/10/16 |
| Checksum(s) interactor A | md5 | rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 |
| Checksum(s) interactor B | md6 | rogid:RA73eMbCn6F7MD0ItxF/V7QbjqM9606 |
| Interaction Checksum(s) | md7 | intact-crc:F4234557A3B54840\ |
| Negative | 是否为负作用 | FALSE |
| Feature(s) interactor A | 特征 | binding-associated region:626-695(MINT-376295) |
| Feature(s) interactor B | binding-associated region:1063-1070(MINT-376288) | |
| Stoichiometry(s) interactor A | - | |
| Stoichiometry(s) interactor B | - | |
| Identification method participant A | 识别方法 | psi-mi:"MI:0078"(nucleotide sequence identification) |
| Identification method participant B | 识别方法 | psi-mi:"MI:0078"(nucleotide sequence identification) |
