The human homologs of Hel25E similarly regulate circRNA localization, as depletion of UAP56 (DDX39B) or URH49 (DDX39A) causes long and short circRNAs, respectively, to become enriched in the nucleus.
Long non-coding RNAs (lncRNA) are defined as sequences longer than 200 nucleotides and are among the most highly transcribed of the non-coding RNAs (Mattick and Makunin 2006).
Long noncoding RNAs (lncRNAs) are operationally defined as transcripts that are larger than 200 nt that do not appear to have proteincoding potential (Kapranov et al., 2007; Mattick and Rinn,
2015).
The reports published by Encyclopedia of DNA elements (ENCODE) revealed that approximately 80.4% of the genome is involved in some sort of biochemical activity including chromatin structure, histone modification and RNA transcription etc. [71]
