1. 基础的指令配置

-optimizationpasses 5 # 指定代码的压缩级别
-dontusemixedcaseclassnames # 混淆后类名都为小写
-dontskipnonpubliclibraryclasses #指定不去忽略非公共的库的类
-dontskipnonpubliclibraryclassmembers #指定不去忽略非公共的库的类的成员
-dontpreverify # 不做预校验的操作
-verbose # 混淆时是否记录日志
-printmapping proguardMapping.txt #生成原类名和混淆后的类名的映射文件
-optimizations !code/simplification/arithmetic,!field/*,!class/merging/*  # 混淆时所采用的算法
-keepattributes *Annotation*,InnerClasses #不混淆Annotation
-keepattributes Signature #不混淆泛型
-keepattributes SourceFile,LineNumberTable #抛出异常时保留代码行号
-ignorewarnings #抑制警告

2. 一些通用的必要配置

#系统类不需要混淆
-keep public class * extends android.app.Activity
-keep public class * extends android.app.Application
-keep public class * extends android.app.Service
-keep public class * extends android.content.BroadcastReceiver
-keep public class * extends android.content.ContentProvider
-keep public class * extends android.app.backup.BackupAgentHelper
-keep public class * extends android.preference.Preference
-keep public class * extends android.view.View
-keep public class com.android.vending.licensing.ILicensingS
-keep class android.support.** {*;}
-keep public class * extends android.app.Fragment

-keepclasseswithmembernames class * {  # 保持 native 方法不被混淆
    native <methods>;
}
-keepclassmembers class * extends android.app.Activity { # 保持自定义控件类不被混淆
    public void *(android.view.View);
}
-keepclassmembers enum * {# 保持枚举 enum 类不被混淆
    public static **[] values();
    public static ** valueOf(java.lang.String);
}
-keep public class * extends android.view.View{# 保持View类不被混淆
    *** get*();
    void set*(***);
    public <init>(android.content.Context);
    public <init>(android.content.Context, android.util.AttributeSet);
    public <init>(android.content.Context, android.util.AttributeSet, int);
}
-keepclasseswithmembers class * {# 保持自定义控件类不被混淆
    public <init>(android.content.Context, android.util.AttributeSet);
    public <init>(android.content.Context, android.util.AttributeSet, int);
}
-keep class * implements android.os.Parcelable { # 保持 Parcelable 不被混淆
    public static final android.os.Parcelable$Creator *;
}
-keepclassmembers class * implements java.io.Serializable {
    static final long serialVersionUID;
    private static final java.io.ObjectStreamField[] serialPersistentFields;
    private void writeObject(java.io.ObjectOutputStream);
    private void readObject(java.io.ObjectInputStream);
    java.lang.Object writeReplace();
    java.lang.Object readResolve();
}
-keep class **.R$* {
 *;
}
-keepclassmembers class * {
    void *(**On*Event);
}

#WebView相关
-keepclassmembers class fqcn.of.javascript.interface.for.Webview {
   public *;
}
-keepclassmembers class * extends android.webkit.WebViewClient {
    public void *(android.webkit.WebView, java.lang.String, android.graphics.Bitmap);
    public boolean *(android.webkit.WebView, java.lang.String);
}
-keepclassmembers class * extends android.webkit.WebViewClient {
    public void *(android.webkit.WebView, java.lang.String);
}

# 其它
-keep class com.google.android.gms.** {*;}
-dontwarn com.google.android.gms.**
-dontwarn com.viewpagerindicator.*
-dontwarn com.amazonaws.**
-dontnote com.google.vending.licensing.ILicensingService
-dontnote com.android.vending.licensing.ILicensingService


# Androidx相关
-keep class com.google.android.material.** {*;}
-keep class androidx.** {*;}
-keep public class * extends androidx.**
-keep interface androidx.** {*;}
-dontwarn com.google.android.material.**
-dontnote com.google.android.material.**
-dontwarn androidx.**

3. 实体类

# 可能会存在多处，需要一一添加
-keep class 包名.bean.** {*;}

4. 第三方Library

# 本地.so库文件声明
-libraryjars libs/armeabi/xxx.so
-libraryjars libs/armeabi-v7/xxx.so
-libraryjars libs/x86/xxx.so

# 常用第三方Library混淆配置
# Glide
-keep public class * implements com.bumptech.glide.module.GlideModule
-keep public class * extends com.bumptech.glide.module.AppGlideModule
-keep public enum com.bumptech.glide.load.resource.bitmap.ImageHeaderParser$** {
  **[] $VALUES;
  public *;
}

# Alipay
-dontwarn com.alipay.**
-dontwarn com.ta.utdid2.**
-dontwarn com.ut.device.**
-dontwarn android.net.**
-keep class com.alipay.** {*;}
-keep class com.ta.utdid2.** {*;}
-keep class com.ut.device.** {*;}
-keep class android.net.SSLCertificateSocketFactory

# butterknife
-keep class butterknife.** {*;}
-dontwarn butterknife.internal.**
-keep class **$$ViewBinder {*;}
-keepclasseswithmembernames class * {
    @butterknife.* <fields>;
}
-keepclasseswithmembernames class * {
    @butterknife.* <methods>;
}

# eventbus
-keepattributes *Annotation*
-keepclassmembers class ** {
    @com.google.common.eventbus.Subscribe <methods>;
        public void onEvent*(**);
        void onEvent*(**);
}
-keep enum de.greenrobot.event.ThreadMode {*;}
-keepclassmembers class * extends de.greenrobot.event.util.ThrowableFailureEvent {
    <init>(java.lang.Throwable);
}

# Gson
-dontwarn com.google.gson.**
-keep class com.google.gson.** {*;}
-keep class sun.misc.Unsafe {*;}

# 科大讯飞相关(ifly_push_sdk && Msc)
-dontwarn com.iflytek.**
-keep class com.iflytek.** {*;}

# 腾讯相关(libammsdk && open_sdk)
-dontwarn com.tencent.**
-keep class com.tencent.** {*;}

# weibosdkcore
-dontwarn com.sina.weibo.sdk.**
-keep class com.sina.weibo.sdk.** {*;}

# Dagger
-dontwarn dagger.internal.codegen.**
-dontwarn javax.inject.**
-keepclassmembers,allowobfuscation class * {
    @javax.inject.* *;
    @dagger.* *;
    <init>();
}
-keep class dagger.** {*;}
-keep class javax.inject.** {*;}
-keep class * extends dagger.internal.Binding
-keep class * extends dagger.internal.ModuleAdapter
-keep class * extends dagger.internal.StaticInjection

这里要注意的一点是，要避免重复声明jar包——如果在build.gradle中使用了compile fileTree(include: ['*.jar'], dir: 'libs')，就不需要在混淆文件中添加-libraryjars libs/xxx.jar去声明对应的jar了，否则会报错提示重复添加。

5. 反射类及其相关方法

-keep class java.lang.annotation.** {*;}

6. JS相关交互类(方法互调)

【拓展阅读】
整理Android最全的混淆规则大全（最新的开源框架混淆）
Android混淆

【声明】
本文部门内容参考自5分钟搞定android混淆，根据实际的需求有所修改整理。