今天要介绍的多肽是一种RGD环肽，名字为c(RGDfK)。
常见写法：cyclo(RGDfK)、cyclo(Arg-Gly-Asp-D-Phe-Lys)、cyclo(Arg-Gly-Asp-DPhe-Lys)、c(RGDfK)，其中c(RGDfK)最为简短，以下介绍都用这个名字。
c(RGDfK)是一个五元环肽，由精氨酸、甘氨酸、天冬氨酸、D型苯丙氨酸、赖氨酸组成，并且首尾酰胺键成环。Arg-Gly-Asp (RGD)序列是纤维连接蛋白中高度保守的整合素识别序列。
The Arg-Gly-Asp (RGD) sequence is a highly conserved integrin recognition sequence within fibronectin.
编号:144182
中文名称:c(RGDfK)
中文同义词:cyclo(RGDfK)
英文名:cyclo(RGD-DPhe-K)
英文同义词:Cyclo(Arg-Gly-Asp-D-Phe-Lys)
CAS号:161552-03-0
单字母:cyclo(RGD-DPhe-K)(main chain cyclo)
三字母:cyclo(Arg-Gly-Asp-DPhe-Lys)(main chain cyclo)
氨基酸个数:5
分子式:C27H41N9O7
平均分子量:603.67
精确分子量:603.31
等电点(PI):9.7
pH=7.0时的净电荷数:0.98
平均亲水性:1.625
疏水性值:-1.9
来源:Synthetic
纯度:95%、98%
盐体系:可选TFA、HAc、HCl或其它
生成周期:当天发货
修饰类型:酰胺键成
环储存条件:-20±5 °C
参考文献：
10.1166/jbn.2014.1721Molecular targeting radiotherapy with cyclo-RGDFK(C) peptides conjugated to 177Lu-labeled gold nanoparticles in tumor-bearing mice
10.1016/j.nucmedbio.2013.01.003Design and biological evaluation of ⁹⁹mTc-N₂S₂-Tat(49-57)-c(RGDyK): a hybrid radiopharmaceutical for tumors expressing α(v)β(3) integrins
10.1039/c2dt31493bCyclization of RGD peptide sequences via the macrocyclic chelator DOTA for integrin imaging
10.1186/bcr2579Novel design principles enable specific targeting of imaging and therapeutic agents to necrotic domains in breast tumors
10.1002/smll.200700148Specific integrin labeling in living cells using functionalized nanocrystals
10.1002/1439-7633(20000818)1:2<107::AID-CBIC107>3.0.CO;2-4Surface coating with cyclic RGD peptides stimulates osteoblast adhesion and proliferation as well as bone formation
