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They may sound like weapons for Ant-Man’s next nemesis, but the microscopic lasers could greatly improve biologists’ ability to
track the movement of individual cells—a possible boon to fields ranging from developmental biology to cancer research.
这篇文章主要是讲制造细胞大小的激光器。它的优势是非常明显的,可以比fluorescence和radio frequency ID更好。
不过要制造一台激光器,就需要有两个条件:
- 能够受到激发而产生光的材料,一般是指晶体
- 一个共振腔
难点在于如何在细胞里装进一个容器
以下尝试:
- In culture, they mixed cells with tiny plastic spheres 5 to 10 micrometers in diameter that had been “doped” with a fluorescent dye. The beads served as the cavities, the dye as the medium.
- get cells to take up plastic beads, and they created two other kinds of resonating spheres as well
那这么做的目的在于什么呢?
- 追踪细胞的运动,每一个细胞的塑料球都是有一点不同,这样他们的激发出来的激光就会有一点波长上的区别。这样就可以分开每个细胞了。
- 每种tissue会吸收不同的beads,那么相比于fluorescence,则有着更大的优势。可以定位millions of cells
难点,更小的beads,更好的吸收。