"目录号: HY-14375
Metabolic Enzyme/Protease-
CB 300919是CB30865的水溶性类似物，对人CH1卵巢癌外植体的IC50为2 nM。
Nampt
相关产品
FK866-GNE-617 hydrochloride-GMX1778-STF-118804-Nampt-IN-1-P7C3-CB30865-
生物活性
Description
CB 300919 is a water-soluble analogue of CB30865; has a continuous exposure (96 h) growth inhibition IC50 value of 2 nM in human CH1 ovarian tumor xenograft.IC50 value:Target: Nampt
References
[1].Lockman JW, et al. Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as Potent Inhibitors of Nicotinamide Phosphoribosyltransferase (Nampt). J. Med. Chem., 2010, 53 (24), pp 8734-87
[2].Bavetsias, V. et al. The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent. Journal of Medicinal Chemistry (2002), 45(17), 3692-3702.
