"目录号: HY-13785
ZM-306416(CB 676475)是VEGFR选择性抑制剂（IC50为670nM），对于Flk-1(KDR)和Flt的IC50分别为100nM和2μM。
相关产品
Sorafenib-Dasatinib-Nocodazole-BIBF 1120-SU5416-Regorafenib-Ponatinib-Sunitinib-Cabozantinib-Nilotinib-Imatinib Mesylate-Vandetanib-Lenvatinib-Saracatinib-Apatinib-
生物活性
Description
ZM-306416(CB 676475) is a VEGFR inhibitor that inhibits Flk-1 (KDR) (IC50=100 nM) and Flt (IC50 =2 μM); displays 4-fold selectivity over FGFR-1; inhibitor of c-Abl, Flt-1 and Src.IC50 Value: 0.67uM(VEGFR); 0.33±0.08uM(Src); 1.3±0.2 μM(Abl)Target: VEGFR; Src; Ablin vitro: 306416 was found to be very potent toward the EGFR kinase with an IC50 value lower than 10 nM, reaching our assay detection limit and confirming our result using the EGFRB assay. ZM-306416 exhibited inhibitory activity across all three kinases of the panel, yielding IC50 values of 0.33±0.08 μM for SRC, 0.33±0.04 μM for VEGFR1, and 1.3±0.2 μM for ABL kinases [1].
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