cell maker
cancer cells: EPCAM, CD24, SOX4, KRT18
T cells: CD2, CD3D, TRAC, TRBC2
Treg: Foxp3, CD25, CD4
B cells: CD79A, CD79B, MS4A1
myeloid cells: LYZ, MNDA, C1QA, VCAN, APOE
fibroblasts: COL1A1, COL1A2, LUM, DCN
CAFs: COL1A1, COL1A2, POSTN, PDGFRA
mural cells: RGS5, MYH11, PDGFRB, NOTCH3
endothelial cells: PECAM1, ENG, PLVAP, CDH5
microglial cells: P2RY12, CX3CR1
oligodendrocytes: OLIG1, OLIG2, MBP, MOG, MAG
other cells: ALB, APOB, HP
ref.: The Single-Cell Landscape of Intratumoral Heterogeneity and The Immunosuppressive Microenvironment in Liver and Brain Metastases of Breast Cancer
lung cancer marker
main cell types:
epithelial cells: EPCAM, CDH1, KRT7, KRT19
immune cells: PTPRC, CD68, KIT, JCHAIN, MS4A1
stromal cells：PECAM1, VMF, ACTA2
epithelial cell types:
alveolar type 1: AGER, PDPN
alveolar type 2: ABCA3, SFTPB, SFTPC
Club cells: SCGB1A1, MUC5B
Basal cells: KRT5, KRT17, NGFR, TRP63
Ciliated cells: FOXJ1, TMEM190, CAPS
Neuroendocrine: ASCL1, CALCA, CHGA
stromal cell types:
Endothelial cells: VWF, PECAM1
Lymphatic endothelial cells: CCL21, PROX1
Fibroblasts: PDGFRA, LUM
Myofibroblasts: PDGFRA, LUM, MYLK, ACTA2, PDGFRB
Smooth muscle cells: MYLK, ACTA2, PDGFRB, MYH11
Mesothelial cells: UPK3B, WT1
Immune cell types:
Alveolar Macrophages: CD68, LYZ, FABP4, MARCO, C1QA, APOC1
Monocyte-derived macrophages: CD69, LYZ, LGMN, CSF1R, CD14
Monocytes: LYZ, S100A12, FCN1, S100A9, CD14
Myeloid dendritic cells: CD1C, FCER1A, CLEC9A
Plasmacytoid dendritic cells: LILRA4, IL3RA, CLEC4C, JCHAIN
Mast cells: KIT, GATA2, CPA3
Conventional T cells: CD3E, IL7R, CD40LG
Regulatory T cells: CD3E, FOXP3, CD40LG
CD8+ T cells: CD3E, CD8A, CCL5
NK cells: NKG7, KLRD1, KLRB1, NCR1
B cells: MS4A1, CD79A, CD19
Plasma cells: JCHAIN, IGKC, IGHG1
ref.: Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma
cell marker
immune cells:
T cells: CD2, CD3D/E/G
CD8+ T cells: CD8A
CD4+ T cells: CD4
CD8+ effector T: GNLY, GZMA, GZMB, GZMK
Naïve T cells: CCR7, LEF1, IL7R, SELL
Exhausted T cells: LAG3, TIGIT,
Regulator T cells: FOXP3, IL2RA, IKZF2
Exhausted T cells, Regulator T cells: CTLA4
Tissue-resident memory T cells: ITGAE, ITGA1, ZNF683
B cells: CD79A/B
Follicular B cells: MS4A1, HLA-DRs, CXCR4
Plasma cells: MZB1, JCHAIN
Myeloid cells: LYZ
Neutrophils: CSF3R, S100A8/9, FCGR3B
Conventional type 1 dendritic cell (cDC1): XCR1, CLEC9A
Conventional type 2 dendritic cell (cDC2): FCER1A, CD1C
Mature dendritic cells: LAMP3
Follicular dendritic cells: FDCSP
Plasmacytoid dendritic cells: IL3RA, LILRA4, CLEC4C
Macrophages: CD68
M2 macrophages/Alternatively activated macrophages: MRC1, CD163
Monocytes: CD14, FCN1
Mast cells: TPSAB1, TPSB2, GATA2
vessel cells:
Endothelial cells：CLDN5, PECAM1, VWF
Tip cells: DLL4, KCNE3, ESM1, ANGPT2
Vein endothelial cells: ACKR1, GJA5
Lymphatic endothelial cells: PROX1, PDPN
Pericytes: RGS5, CSPG4
stroma cells:
Fibroblasts: DCN, COL1A1/2
Myofibroblasts: ACTA2, MYH11
epiphelial cells:
Epithelial cells: CAPS, SNTN
Alveolar cells: CLDN18, AQP4
Alveolar type 1 cells: CAV1, AGER
Alveolar type 2 cells: SFTPC, SFTPA1, ABCA3
Club cells: SCGB1A1, SCGB3A1
Basal cells: KRT5, KRT6A, KRT14
Ciliated cells: FOXJ1, TPPP3, PIFO
