"目录号: HY-13662A
Membrane Transporter/Ion Channel-
Lansoprazole钠(AG-1749)是质子泵抑制剂，能抑制胃酸生成。
相关产品
TAK-438-Omeprazole-Pantoprazole sodium-(R)-Lansoprazole-Zinc Pyrithione-AZD0865-Ilaprazole-Esomeprazole Magnesium trihydrate-Bamaquimast-Rabeprazole sodium-Soraprazan-Chebulinic acid-Picoprazole-SKF96067-Tenatoprazole sodium-
生物活性
Description
Lansoprazole sodium(AG-1749) is a proton pump inhibitor which prevents the stomach from producing acid.Target: Proton PumpLansoprazole (sodium) is sodium salt form of lansoprazole, lansoprazole, a substituted benzimidizole proton pump inhibitor, on pharmacokinetics and metabolism of theophylline has been studied in healthy adults given oral lansoprazole 30 mg once daily for 11 days. On Days 4 and 11 of 300 mg aminophylline was simultaneously administered orally and blood samples for theophylline analysis were taken over 24 h [1]. Patients in the lansoprazole group were significantly less likely to have a recurrence of ulcer complications than patients in the placebo group (P=0.008). There was no significant difference in mortality between the two groups [2]. lansoprazole (AG-1749) and omeprazole, were found to have significant activities against this organism. The activity of lansoprazole was comparable to that of bismuth citrate, with MICs ranging from 3.13 to 12.5 micrograms/ml, and fourfold more potent than that of omeprazole [3]. Clinical indications: Duodenal ulcer; Esophagitis; Gastroesophageal reflux; Gastrointestinal disease; Helicobacter pylori infection; Peptic ulcer; Stomach ulcer; Ulcer; Zollinger-Ellison syndromeFDA Approved Date: May 10, 1995Toxicity: Symptoms of overdose include abdominal pain, nausea and diarrhea.
Clinical Trial
Takeda
Esophagitis-Reflux
June 2003
Phase 2
Takeda
Gastroesophageal Reflux Disease With Dyspepsia Symptoms
December 2008
Dr. Reddy's Laboratories Limited
Healthy
December 2008
Phase 1
National Taiwan University Hospital-Takeda
Functional Dyspepsia
December 2009
Phase 4
Seoul National University Hospital
Preterm Infants-Gastrointestinal Reflux
January 2013
Phase 2
Takeda
Acute Stress Ulcer and Acute Gastric Mucosal Lesions
January 2007
Novartis
Frequent Heartburn
January 2007
Phase 3
Takeda
Gastric Ulcer, Duodenal Ulcer, Acute Stress Gastritis, and Acute Gastric Mucosal Lesions
January 2007
Takeda
Gastroesophageal Reflux
June 2002
Phase 4
Novartis
Heartburn
June 2006
Phase 3
Perle Bioscience, Inc.
Type 1 Diabetes
September 2014
Phase 3
Takeda
Gastric or Duodenal Ulcers
August 2010
Takeda
Gastroesophageal Reflux Disease
July 2012
Phase 2
Takeda
Gastric or Duodenal Ulcers
October 2010
Teva Pharmaceuticals USA
Healthy
May 2004
Phase 1
Takeda
Gastroesophageal Reflux Disease
January 2005
Phase 1
Teva Pharmaceuticals USA
Healthy
August 2003
Phase 1
Teva Pharmaceuticals USA
Healthy
January 2004
Phase 1
Far Eastern Memorial Hospital
Respiratory Failure
June 2009
Phase 4
AstraZeneca
Erosive Esophagitis
December 2002
Phase 4
Takeda
Gastroesophageal Reflux Disease
May 2005
Phase 1
Janssen Korea, Ltd., Korea
Reflux Esophagitis
May 2007
Phase 4
Takeda
Stomach Ulcer-Duodenal Ulcer
April 2007
Phase 3
Arkansas Children's Hospital Research Institute
Cystic Fibrosis
June 2006
Phase 1
AstraZeneca
Heartburn-Gastroesophageal Reflux Disease
June 2002
Phase 4
Takeda
Stomach Ulcer-Duodenal Ulcer
May 2007
Phase 3
AstraZeneca
Erosive Esophagitis
December 2002
Phase 4
Takeda
Bioavailability
February 2014
Phase 1
American Institute for Voice and Ear Research
Laryngopharyngeal Reflux
August 2006
Phase 4
Sanford Health-Juvenile Diabetes Research Foundation
Type 1 Diabetes
August 2010
Phase 2
Takeda
Esophagitis, Reflux-Esophagitis, Peptic
December 2005
Phase 3
Takeda
Esophagitis, Reflux-Esophagitis, Peptic
December 2005
Phase 3
Takeda
Gastroesophageal Reflux Disease
June 2006
Phase 3
Takeda
Pediatric Gastroesophageal Reflux Disease
February 2016
Phase 1
Lotung Poh-Ai Hospital-Tomorrow Medical Foundation
Functional Dyspepsia-Epigastric Pain Syndrome-Post Prandial Distress Syndrome
May 2008
Phase 4
Takeda
Erosive Esophagitis
April 2015
Phase 3
Takeda
Gastroesophageal Reflux Disease-Erosive Esophagitis-Heartburn
February 2014
Phase 1
Charles Mel Wilcox, MD-Takeda Pharmaceuticals North America, Inc.-University of Alabama at Birmingham
Zollinger-Ellison Syndrome-Multiple Endocrine Neoplasia
March 2003
Phase 4
AstraZeneca
Barrett's Esophagus
January 2006
Phase 4
Seoul National University Hospital
Gastroesophageal Reflux Disease
December 2009
Takeda
Gastroesophageal Reflux
November 2015
Phase 2
Puma Biotechnology, Inc.
Healthy
August 2014
Phase 1
Indiana University
Laryngopharyngeal Reflux
March 2011
Takeda
Barrett's Esophagus
July 2014
Phase 2
Vanderbilt University-TAP Pharmaceutical Products Inc.
Larynx Disease
August 2006
Phase 3
Takeda
Gastric Ulcer-Peptic Ulcer-Gastrointestinal Diseases-Digestive System Diseases-Lansoprazole-Anti-Ulcer Agents-Gastrointestinal Agents-Proton Pump Inhibitors-Enzyme Inhibitors-Molecular Mechanisms of Pharmacological Action
April 17, 2017
Phase 3
Takeda
Gastroesophageal Reflux Disease-Erosive Esophagitis
July 2012
Phase 2
Xijing Hospital
Healthy
March 2013
Phase 1
Takeda
Erosive Esophagitis
December 31, 2016
Phase 3
Takeda
Erosive Esophagitis
