"目录号: HY-15197
ABT-046是高活性、口服生物相容性的二酰基甘油酰基转移酶1（DGAT-1）抑制剂，IC50为8 nM。
相关产品
LCQ-908-A 922500-T863-PF-04620110-AZD7687-DGAT-1 inhibitor 2-Xanthohumol-DGAT1-IN-1-
生物活性
Description
ABT-046 is a potent, selective, and orally bioavailable Diacylglycerol acyltransferase 1 (DGAT-1 ) inhibitor (IC50= 8 nM).IC50 value: 8 nM [1]Target: DGAT-1Oral administration at doses ≥0.03 mg/kg significantly reduced postprandial triglycerides in mice following an oral lipid challenge. Further assessment in both acute and chronic safety pharmacology and toxicology studies demonstrated a clean profile up to high plasma levels, thus culminating in the nomination of 14 as clinical candidate ABT-046.
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